Endocrine Abstracts

Hyperthyroidism in Graves’ disease (GD) is caused by thyroid-stimulating autoantibodies to the TSH receptor. Hypothyroidism in Hashimoto’s thyroiditis (HT) is associated with thyroid peroxidase and thyroglobulin autoantibodies. Transformation of HT to GD has been rarely reported. We report a woman with history of HT, who then developed GD.Case presentation: A 50-year-old female with a past history of hypothyroidism due to HT treated with Levo...

Objective: We present a case of hypertriglyceridemia induced acute pancreatitis (HTG-AP) and concurrent diabetic ketoacidosis (DKA) as a first presentation of Diabetes Mellitus in an adult patient. This uncommon triad has been previously described in the literature, however, it is rare to be observed in a previously undiagnosed patient with diabetes. The purpose of this poster is to describe the potential mechanisms for this and discuss management strategies.<p class="abst...

Background: The short Synacthen test (SST) is used primarily to diagnose adrenal insufficiency (AI), with hyponatraemia being among the commonest indications. Given the national shortage of tetracosactide and following cases of test mismanagement highlighted by our Biochemistry department, we investigated the indications, appropriate patient selection and performance of this test.Methods: A retrospective analysis of 117 cases identified to have a SST per...

Hyperthyroidism is rarely associated with malignancy. Some cases of co-existing between hyperthyroidism and thyroid carcinoma have been described. We report a case of association of a toxic thyroid nodule and papillary microcarcinoma.Observation: A 50-year-old male was referred to the endocrinologist for hyperthyroidism (TSH: 0.01 mUI/l, FT4: 22.8 pmol/l, FT3: 17.1 pmol/l). Thyroid ultrasonography showed a nodule of 38 mm in the left lobe. 99 mTc thyroid...

A previously well 54 year old man, with no atherosclerotic risk factors, presented with a 10 month history of claudication. Arteriography showed extensive distal aortic and iliac stenoses.At surgery, (Aortoiliac and femoral bypass) extensive thrombus was found in the distal aorta. Post operatively good distal flow was confirmed. He was discharged on Aspirin.Fourteen days later the patient was readmitted hypotensive, pyrexic, with ...

Maternal hypothyroidism disrupts fetal brain development in the rat; affected parameters include several neuron-specific cytoskeletal proteins and neurotransmitter metabolic enzymes. The aim of this study was to determine whether maternal hyperthyroidism also impacts upon fetal neuronal development.Partially thyroidectomised rat dams were subcutaneously implanted with osmotic pumps to infuse either 1.5 micrograms thyroxine/100 g body weight/day (HYPER) o...

Introduction: The 250 μg cosyntropin stimulation test (CST) is used to diagnose non-classic congenital adrenal hyperplasia (NCCAH). The current recommendation to perform CST is when follicular morning 17-hydroxyprogesterone (17OHP) is higher than 6 nmol/l, and CST is considered positive for NCCAH diagnosis when the 60-minutes post-CST 17OHP serum level is above 30 nmol/l. These cut offs are mainly derived from radioimmunoassay (RIA) data. Recently, a validated enzyme-link...

We present a case of a 56 year-old man diagnosed with systemic mastocytosis by the dermatologists on presentation with classical skin lesions, confirmatory bone marrow biopsy and a tryptase level 105 ug/L (NR 2-14). Further genetic testing confirmed KIT D816V mutation. DEXA bone densitometry at diagnosis revealed marked osteoporosis (Lumbar T score -3.7 (Z -3.5), Femoral Neck T score of -2.0 (Z -1.1). He had no history of low trauma fracture and no relev...

We present a case of a 56 year-old man diagnosed with systemic mastocytosis by the dermatologists on presentation with classical skin lesions, confirmatory bone marrow biopsy and a tryptase level 105 ug/L (NR 2-14). Further genetic testing confirmed KIT D816V mutation. DEXA bone densitometry at diagnosis revealed marked osteoporosis (Lumbar T score -3.7 (Z -3.5), Femoral Neck T score of -2.0 (Z -1.1). He had no history of low trauma fracture and no relev...

Objective: Vaccination against coronavirus disease 2019 (COVID-19) an important component of coping with the pandemic. Anecdotal cases and case series reported an association between COVID-19 vaccination and the development of Graves’ disease. We used data from Israel’s largest health care organization to determine whether COVID-19 vaccination was associated with the incidence of Graves’ disease.Methods: We analyzed data from Clalit Health...